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Custom Service Request

NEWS

Cell Biologics provides custom services to our customers upon request.

Adult stem cell analysis (Human and Mouse Cells) 

We provide extensive adult stem cell analysis including hematopoietic stem cells, intestinal stem cells, spermatogonial stem cells and so on.

1. Hematopoietic stem cells: phenotypic analysis, colony-forming assay, spleen colony assay, hematopoieticstem cell transplantation assay, etc.

2. Intestinal stem cells:  phenotypic analysis, differentiation assay including numbers of goblet cells, endocrine cells, Paneth cells, etc.

3. Spermatogonial stem cells: phenotypic analysis, Spermatogonial stem cell transplantation assay. 

Surgical and Functional Assessment Services 

1.     Myocardial infarction and reperfusion

2.      Trans aortic constriction pressure overload model

3.      Mouse Lung orthotopic transplantation

4.      Mouse lung ischemia and reperfusion injury

5.      Mouse kidney ischemia and reperfusion injury

6.      Mouse Skin transplantation

7.      Mouse Parabiosis

Cell Biologics' products can be purchased through Fisher Scientic by searching Cell Biologics' product catalog number or key words...

PROMOTIONS


  • Buy 3 Get 1 Free on Mouse and Rat Hepatocytes.

Promo Code: CBHP0324, before March, 2024

  • Buy 3 Get 1 Free on Mouse and Rat Macrophages

Promo Code: MC0324 before March 2024.

NEW PRODUCT

  • Transfected Stable Cell Lines - Inquiry

  • Gene Knockdown Stable Cell Lines - Inquiry

  • Gene Knockout Stable Cell Lines - Inquiry

  • Gene Overexpression - Inquiry

  • miRNA Overexpression Stable Cell Lines - Inquiry
Featured Cells

Recombinant Human MSTN

Recombinant Human MSTN
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Price: $0.00
Cat. #: Z100067

Available Options:
Sequence:
Purity:
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Qty: Buy Quote

Related Documents:
Growth differentiation Factor 8 (GDF-8), also known as myostatin, is a secreted protein that is expressed specifically in developing and adult skeletal muscle. It controls myoblast proliferation and is a potent negative regulator of skeletal muscle mass. GDF-8 belongs to the transforming growth factor beta (TGF-beta) superfamily, which includes the TGF-betas, bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs), activins, inhibins, leftys, nodal, Mullerian inhibitory substance (MIS) and the glial cell line-derived neurotrophic factors (GDNFs). All TGF-_ superfamily members are synthesized and secreted as a homodimeric prepropeptide that is cleaved by proprotein convertases such as furin to generate the dimeric N-terminal propeptide and the dimeric C-terminal mature active protein. The C-terminal mature protein contains the characteristic conserved cysteine residues involved in the formation of the cysteine knot domain. Mouse GDF-8 cDNA encodes a 376 amino acid residue (aa) preproprotein with a putative 24 aa signal peptide, a 243 aa propeptide and a 109 aa mature protein. As is the case with most TGF-beta family proteins, GDF-8 is highly conserved across species. Mature human, mouse, rat, and cow GDF-8 share 100% aa sequence identity. Among TGF-beta family members, GDF-8 is most closely related to GDF- 11/BMP-11. The two proteins share 65% overall aa sequence, within their mature regions, the two proteins differ only by 11 aa.residues. Similarly to TGF-beta-1, 2, and 3, the GDF-8 homodimeric propeptide and mature protein remained non- covalently linked after proteolytic cleavage, and is released as a biologically inactive latent complex that does bind its receptor. In serum, GDF-8 has also been found to exist in a large latent complex that also included FLGR (follistatin-related gene) and GASP-1 (growth and differentiation factor- associated serum protein-1) in addition to the propeptide. R&D Systems recombinant GDF-8 propeptide is capable of associating with the active GDF-8 with high-affinity to reconstitute the latent complex and is potent GDF-8 antagonist.
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